犬新孢子虫感染引起的坏死性小脑炎和小脑萎

NecrotizingCerebellitisandCerebellarAtrophyCausedbyNeosporacaninumInfection:MagneticResonanceImagingandClinicopathologicFindingsinSevenDogs

L.Garosi,A.Dawson,J.Couturier,L.Matiasek,A.deStefani,E.Davies,N.Jeffery,andP.Smith

Adultdogswithneosporosiscandevelopavarietyofneurologicsigns.Noareaofpredilectionwithinthenervoussystemsofarhasbeenidentifiedinadultdogs.

Objectives:Todocumentneosporosisasacauseofprogressivecerebellarataxiaandcerebellaratrophyindogs.Animals:Sevenclient-owneddogs.Methods:Retrospective,descriptivestudy.Results:Ageatdiagnosisrangedfrom1year6monthsto9years11months.Neuroanatomiclocalizationindicatedcer-

ebellarandbrainstemdiseasein6dogsandacentralvestibularlesionin1dog.Inall7dogs,therewasmoderatetomarkedbilaterallysymmetricalcerebellaratrophy,withtheatrophiedcerebellumbeingsurroundedbyaregionofT2-weightedhyper-intenseandT1-weightedhypointensesignal.Cerebrospinalfluid(CSF)analysisinallbut1dogshowedmononuclearpleocytosisandhighproteinconcentration.PolymerasechainreactiontestingforNeosporacaninumperformedontheCSFwaspositivein4/5dogstestedandtherewasahightiterofserumantibodiestoN.caninum(??1:)inall6dogstested.Postmortemexaminationin1dogconfirmedcerebellaratrophyandmultifocalnonsuppurativeencephalitiswithareasofmalaciaandleptomeningitis.Alloftheremaining6dogsweretreatedwithsome

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